To maximize the effectiveness of this build you will absolutely want to complete a few side quests and associate with a few followers in particular. Much like the melee build we have mostly focused on taking the perks that will enable us to deal more damage with our hand-to-hand attacks to kill enemies before they deal too much damage. There are a few areas where you can talk your way out of fighting entirely which is very helpful during any unarmed playthrough. While increasing the three Tagged Skills, especially Unarmed and Sneak, you will also want to increase Speech.